解剖学和形态学
麻醉学
听力与言语-语言病理学
行为科学
心脏和心血管系统
细胞和组织工程学
临床神经病学
危重症监护医学
牙科,口腔外科和医学
皮肤病学
急诊医学
内分泌学和新陈代谢
肠胃学和肝脏学
老人病学和老年医学
卫生保健科学和服务
血液学
免疫学
传染病
综合和补充性医学
医学伦理学
医学信息学
医学实验室技术
医学,全科和内科
医学,法律
医学,研究和试验
神经系统科学
护理
营养学和饮食学
产科医学和妇科医学
肿瘤学
眼科学
整形外科学
耳鼻喉科学
病理学
儿科学
周围血管疾病
药理学和药剂学
生理学
基本医疗保健
精神病学
公共、环境和职业卫生
放射学,核医学和医学成像
康复学
生殖生物学
呼吸系统
风湿病学
运动科学
外科学
毒理学
热带医学
泌尿学和肾脏学
病毒学
老年医学
健康政策和服务
心理学,临床
abstract::Chemical agents including 5-iodo-2'-deoxyuridine (IUdR), 4-O-methyl 12-O-tetradecanoyl phorbol-13-acetate (TPA), phorbol, and the tumor promoters teleocidin and TPA were tested for their ability to induce Human T-cell leukemia-lymphoma virus Type I (HTLV-I) expression in the low-virus producer MT-1 cell line and in th...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/0304-3835(88)90077-8
更新日期:1988-04-01 00:00:00
abstract::The pharmacological specificity of adrenergic receptors in the plasma membrane of rat ascites hepatoma AH130 cells was compared with that in normal rat hepatocytes. The number of [125I]iodocyanopindolol-binding sites was much greater in AH130 cells than in the hepatocytes. We characterized the alpha-adrenergic recepto...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/0304-3835(88)90069-9
更新日期:1988-04-01 00:00:00
abstract::In experimental cancer chemoprevention studies, the doses of the agent used to produce an inhibitory response are generally very high, sometimes bordering on levels that will result in toxicity to the test animals. The present study was designed to test the hypothesis that low doses of two or more agents may be just a...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/0304-3835(88)90066-3
更新日期:1988-04-01 00:00:00
abstract::d-Alpha tocopheryl succinate (vitamin E succinate), which inhibited growth and survival, and induced differentiation in murine B-16 melanoma cells in culture, increased adenosine 3',5'cyclic monophosphate-(cAMP)-dependent protein kinase (PK) activity without increasing the cellular cAMP level. Prostaglandin (PG)A2, wh...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/0304-3835(88)90097-3
更新日期:1988-03-01 00:00:00
abstract::Difluoro-phenyl-ethyl(4-aminopropylamidinohydrazone) (DFPA) was synthesized as an irreversible inhibitor of ornithine and S-adenosylmethionine decarboxylases and analyzed for antiproliferative effects on leukemia cells. The compound irreversibly inhibited ornithine and S-adenosylmethione decarboxylases. This inhibitio...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/0304-3835(88)90096-1
更新日期:1988-03-01 00:00:00
abstract::The effects of 3-aminobenzamide (ABA), a representative inhibitor of poly(ADP-ribose)polymerase, on the induction of gamma-glutamyl-transpeptidase (GGT)-positive foci, an early lesion occurring during hepatocarcinogenesis, in rat liver by various chemicals were studied in Fischer 344 and Wistar rats. ABA exhibited an ...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/0304-3835(88)90037-7
更新日期:1988-02-01 00:00:00
abstract::Treatment of mouse lymphoma L5178Y cells with spermine in Fischer's medium containing bovine serum lead to formation of chromatid aberrations. The cause of this effect seems to be that bovine serum contains spermine oxidase which catalyzes oxidation of spermine to unstable aldehyde derivatives (oxidized spermine) and ...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/0304-3835(88)90044-4
更新日期:1988-02-01 00:00:00
abstract::Rectal biopsies and fecal collections were obtained from a consecutive series of 34 outpatients prior to colonoscopy at a gastroenterology clinic. Subsequently, 14 were found to have no colonic pathology, 13 had adenomatous polyps, (3 of those had a previous history of colon cancer) and 7 were diagnosed with colon can...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/0304-3835(88)90023-7
更新日期:1988-01-01 00:00:00
abstract::The effects of vitamin E, vitamin B2 and selenite on DNA single strand breaks induced by Na2CrO4 were examined by alkaline elution. Incubation of Chinese hamster V-79 cells with alpha-tocopherol succinate (vitamin E) for 24 h prior to exposure to Na2CrO4 resulted in a decrease of DNA breaks produced by this compound. ...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/0304-3835(87)90193-5
更新日期:1987-12-01 00:00:00
abstract::The uptake of several metallophthalocyanine tetrasulfonates by cultured Chinese hamster cells was studied. Uranyl- and chloraluminium were taken up at the highest rate followed by Ni-, Zn-, Cu-, Co- and dichlorosilicon-phthalocyanine tetrasulfonate. The uptake from the growth medium containing 10% serum in which only ...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/0304-3835(87)90217-5
更新日期:1987-12-01 00:00:00
abstract::Mangiferin, a naturally occurring glucosylxanthone, was assessed for its immunomodulatory potential. The phytochemical induced extensive in vitro proliferation of murine splenocytes and thymocytes at the doses of 5-40 micrograms ml-1. Suppression of the proliferative response of the cells was observed with higher dose...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/0304-3835(87)90114-5
更新日期:1987-11-01 00:00:00
abstract::The induction of differentiation of SENCAR murine granulocyte-macrophage precursor cells (GM-CFU) by the tumor-promoting phorbol diester 12-O--tetradecanoyl-phorbol-13-acetate (TPA) was inhibited by agents reported to inhibit specific aspects of arachidonic acid metabolism. These agents included phospholipase A2 inhib...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/0304-3835(87)90109-1
更新日期:1987-11-01 00:00:00
abstract::In the present study a methodological approach is taken which quantitates aberrant dysplastic crypts in the unsectioned murine colon. C57BL/6J or CF1 female mice (7-8 weeks old) were injected (i.p.) with azoxymethane (5 mg/kg body wt./week) for 4 weeks. Their colons were excised, cut open on the median axis and fixed ...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/0304-3835(87)90157-1
更新日期:1987-10-30 00:00:00
abstract::Relative frequencies of diethylnitrosamine (DEN)-initiated foci of altered hepatocytes appearing in response to promotion by either dietary phenobarbital or a topically applied coal-derived organic mixture (CDM) were investigated in male and female rats. The focus population was examined for two histochemical markers,...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/0304-3835(87)90155-8
更新日期:1987-10-30 00:00:00
abstract::Administration of mannoheptulose partially protected mice infected with Listeria monocytogenes against the lethal effect of a subsequent endotoxin challenge. The ability of these animals to produce tumour necrosis factor was however unaffected. Mannoheptulose was observed to reverse the hypoglycaemic effect of endotox...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/0304-3835(87)90143-1
更新日期:1987-10-01 00:00:00
abstract::Azelaic acid has been shown to inhibit thioredoxin reductase (TR) at the surface of guinea pig and human skin, on cultures of human keratinocytes, melanocytes, melanoma cells, murine melanoma cells (Cloudman S91), and on purified enzymes from Escherichia coli, rat liver, and human melanoma. Human melanoma cells are mo...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/0304-3835(87)90023-1
更新日期:1987-09-01 00:00:00
abstract::The effect of a methyl substituent at the non-benzo ring bay-region position of benzo[e]pyrene (B[e]P), cholanthrene (CA) and dibenz[a,j]anthracene (DB[a,j]A) on skin tumor-initiating activity was examined. A methyl substituent at the 1-carbon of B[e]P enhanced tumor-initiating activity of the parent compound (0.18 vs...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/0304-3835(87)90025-5
更新日期:1987-09-01 00:00:00
abstract::Dietary retinyl palmitate was administered for 22-30 weeks in CD-1 mice which had been initiated with 0.15 mumol of 7,12-dimethylbenz[a]anthracene (DMBA) and promoted with 8 nmol of 12-O-tetradecanoylphorbol-13-acetate (TPA) twice weekly thereafter. This treatment resulted in a dose response in both the tumoricidal ca...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/0304-3835(87)90089-9
更新日期:1987-08-01 00:00:00
abstract::Dioxane, perchloroethylene, and trichloroethylene were investigated as rat liver altered foci promoters in an initiation/promotion protocol. Animals were initiated with diethylnitrosamine, 30 mg/kg, injected i.p. 24 h after 2/3 partial hepatectomy. The chemical under study was administered by gavage once a day, 5 time...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/0304-3835(87)90099-1
更新日期:1987-07-01 00:00:00
abstract::Semi-permeable magnetic microcapsules containing polyethyleneimine (PEI) have been developed as retrievable carcinogen traps. In vitro, the soluble core PEI and membrane both bound reactive substances of limited aqueous stability, such as from [14C]N-methyl-N-nitrosourea ([14C]NMU), and aqueous stable dyes of molecula...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/0304-3835(87)90101-7
更新日期:1987-07-01 00:00:00
abstract::Normal mouse vaginal epithelial cells isolated from ovariectomized ca. 40-day-old BALB/cCrg1 mice were purified by Percoll density gradient centrifugation and grown in primary culture using a collagen gel matrix and a serum-free complete medium. During the 9-day culture period, a 6-fold increase in cell number was obs...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/0304-3835(87)90124-8
更新日期:1987-06-01 00:00:00
abstract::The plant species Ephedra is commonly used in both folk medicine and for the preparation of health teas. Nitrosation of a tea made from Ephedra altissima yielded N-nitrosoephedrine (NEP), N-nitrosopseudoephedrine (NPEP), N-nitrosoproline (NPRO), N-nitrosomethylbenzylamine (NMBA), trace quantities of 2 unidentified non...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/0304-3835(87)90045-0
更新日期:1987-05-01 00:00:00
abstract::The inhibitory effects of some scavengers of oxygen radicals were studied, using a two-stage transformation assay system in vitro 3-methylcholanthrene (3-MC)-initiation and 12-O-tetradecanoylphorbol-13-acetate-(TPA)-promotion in Balb 3T3 cells. Mannitol, a scavenger for hydroxyl radicals, strongly inhibited the TPA-en...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/0304-3835(87)90041-3
更新日期:1987-05-01 00:00:00
abstract::Cytotoxic effects of 3-deazaguanosine (3-DGUO) result from the inhibition of DNA synthesis and incorporation of the drug into DNA. Synergistic antiproliferative effects of a combination of 3-deazaguanosine and 2-beta-D-ribofuranosylthiazole-4-carboxamide, a potent inhibitor of inosine monophosphate dehydrogenase, was ...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/0304-3835(87)90061-9
更新日期:1987-04-01 00:00:00
abstract::The di-methyl-, di-ethyl-, di-propyl-, di-normal butyl-, and di-iso-butyl-ethers of hematoporphyrin were synthesized and shown to possess chromatographic properties similar to those of the tumorlocalizing components of hematoporphyrin derivative (Hpd). The cellular uptake of these ethers, as well as their retention in...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/0304-3835(87)90178-9
更新日期:1987-03-01 00:00:00
abstract::To examine the role of diabetes in pancreatic cancer, 4 groups of Chinese hamsters--2 from genetically diabetic and 2 from non-diabetic lines--were treated with N-nitrosobis(2-oxo-propyl)amine (BOP) at different dose levels and intervals. In one group (referred to as the VA group), BOP was given weekly at a 5 mg/kg bo...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/0304-3835(87)90014-0
更新日期:1987-02-01 00:00:00
abstract::In view of the controversy that exists regarding the histamine content and diamine oxidase activity in relation to human carcinomatous growths, the present investigation was undertaken and carcinomatous tissues of skin, breast and rectum were analysed. The result of the experiment gives a clear evidence that both hist...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/0304-3835(87)90012-7
更新日期:1987-02-01 00:00:00
abstract::Putrescine (PU), spermidine (SPD) and spermine (SPM) levels in blood serum of MC Sa 1828 P-bearing rats have been studied in relation to tumour weight and the histological picture. A statistically significant increase of PU and SPD was found in the course of tumour development. Decrease in the level of polyamines in t...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/0304-3835(87)90073-5
更新日期:1987-01-01 00:00:00
abstract::Application of a single high dose of 7,12-dimethylbenz[a]anthracene (DMBA, 1 mg) or N-nitrosomethylurea (NMU, 0.4 mg) to the ears of either athymic nu/nu or phenotypically normal nu/+ mice (BALB/c background) resulted in the appearance of cutaneous sebaceous adenomas as well as squamous cell tumors, both at the site o...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/0304-3835(86)90069-8
更新日期:1986-12-01 00:00:00
abstract::Fibronectin concentration was determined in plasma from 97 patients with benign or malignant breast disease and from 62 controls. Median plasma fibronectin concentration (microgram FN/ml plasma) appeared to be significantly higher in patients with non-metastatic or metastatic breast cancer as compared to age-matched c...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/0304-3835(86)90071-6
更新日期:1986-12-01 00:00:00
abstract::The Syrian hamster embryo cell transformation assay has been used to investigate the effect of two synthetic antioxidants on morphological transformation induced by the initiator benzo[a]pyrene (BP). A two-stage protocol was employed with an initiation phase of 2 days and a subsequent promotion phase of 5 days. When 1...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/0304-3835(86)90024-8
更新日期:1986-11-01 00:00:00
abstract::Serum beta-glucuronidase activity is shown to differ quantitatively in the following strains of mice, listed in order of increasing activity: C3H, C57BL/6 less than BALB/c, DBA/2, ICR less than SENCAR, A/He. The level of the enzyme in the murine strains is shown to correlate with the urinary excretion of 17-ketosteroi...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/0304-3835(86)90098-4
更新日期:1986-10-01 00:00:00
abstract::The thiol N-acetylcysteine (NAC), a precursor of intracellular glutathione (GSH), efficiently prevented the induction of lung tumors in Swiss albino mice, when supplemented to the diet (0.2%) both before and after an i.p. injection of the carcinogen urethan (ethyl carbamate). Irrespective of urethan administration, NA...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/0304-3835(86)90175-8
更新日期:1986-09-01 00:00:00
abstract::Transforming growth factors (TGFs) are implicated in malignancy, therefore qualitative and quantitative differences of these growth factors in chronic myelogenous leukemia (CML) in chronic phase has been investigated in this report. Induction of anchorage independent growth of BALB/c 3T3 and NRK-49F fibroblasts was us...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/0304-3835(86)90181-3
更新日期:1986-09-01 00:00:00
abstract::Free hematoporphyrin administered intravenously to healthy rabbits (1-28 mg/kg body weight) is bound by the 3 major lipoprotein components of plasma (VLDL, LDL and HDL) with different efficiency. In vitro-prepared complexes of hematoporphyrin (Hp) with lipoprotein fractions isolated from mouse serum have been injected...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/0304-3835(86)90112-6
更新日期:1986-08-01 00:00:00
abstract::Ascorbate anion and glutathione were found to inhibit the aqueous reaction between nitrogen dioxide (NO2) and morpholine (MOR) and thereby prevented the formation of N-nitrosomorpholine (NMOR) and N-nitromorpholine (NTMOR) at both pH 7.4 and 12.5. These antioxidants are approximately 3 orders of magnitude more reactiv...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/0304-3835(86)90042-x
更新日期:1986-07-01 00:00:00
abstract::The therapeutic efficacy of antineoplastic purine analogs can be jeopardized by the emergence of drug-resistant mutant subpopulations of tumor cells. To determine whether such mutant populations might be eradicable in vivo with the type of HAT combination (hypoxanthine + an antifolate + thymidine) known to be selectiv...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/0304-3835(86)90152-7
更新日期:1986-06-01 00:00:00
abstract::Two human prostate tumor cell lines which exhibit a 2.4-fold difference in sensitivity to cis-platinum (cis-Pt) were found to possess slightly different sulphydryl contents, and the presence of a metallothionein-like zinc-binding protein was demonstrated in the line exhibiting relative resistance to cis-Pt. Although t...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/0304-3835(86)90007-8
更新日期:1986-05-01 00:00:00
abstract::Fludarabine phosphate is a synthetic analog of beta-arabinofuranosyl adenine (beta-ara-A), an anti-viral agent. Since beta-ara-A has been shown to be an effective inhibitor of potentially lethal damage (PLD) repair in cell culture system but ineffective in in vivo tumors, we carried out experiments to determine whethe...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/0304-3835(86)90168-0
更新日期:1986-04-01 00:00:00
abstract::The phthalocyanines are a new class of photosensitizers with promising properties for use in photodynamic therapy of cancer [E. Ben-Hur and I. Rosenthal (1985) Int. J. Radiat. Biol., 47, 145--147]. The ability of aluminum phthalocyanine tetrasulfonate (AlPCS) to cause membrane damage upon light exposure was tested usi...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/0304-3835(86)90057-1
更新日期:1986-03-01 00:00:00